Taken from the Sleeve:

Leonard Shelby remembers everything up to thenight his wife was brutally raped and murdered. But since that tradgedy, he has suffered from short-term memor loss and cannot recall any event, the places he has visited or anyone he has met just minutes before.

Determined to find out why his wife was killed, the only way he can store evidence is on scraps of paper, by taking polaroid photos and tattooing vital clues on his body. Throughout his investigation, he appears to have the help of both bartender Natalie, who may have her own secret agenda and police officers Teddy whose friendship is always suspect. As Shelby's fractrued memory tries to piece together a chilling jigsaw of deceit and betrayal in reverse, breathtaking twists and surpriseing turns rapidly occur in the most challenging, original and critically aclaimed thriller in years!